cholesterol biosynthesis pathway

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FDFT1, CT (FDFT1, Squalene synthase, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltr...
FDFT1, CT (FDFT1, Squalene synthase, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltr... by MyBioSource

  • Tested: ELISA (EL/EIA), Western Blot (WB)
  • Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
  • presqualene-di-diphosphate synthase; farnesyl-diphosphate...

Product Description
SynName: Anti -FDFT1, CT (FDFT1, Squalene synthase, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase); FDFT1, CT (FDFT1, Squalene synthase, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase); *Specificity: HumanImmunogen: FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 amino acids from the C-terminal region of human FDFT1.; *Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.; *Accession#: CAG33314.1; Q6IAX1; *Description: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.; *NCBI Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Human Cholesterol 7alpha-Hydroxylase, CYP7A ELISA Kit (ELISA Kit)
Human Cholesterol 7alpha-Hydroxylase, CYP7A ELISA Kit (ELISA Kit) by MyBioSource

  • Sample Volume: 50-100ul; *Protein Biological Process 1:...
  • cholesterol 7 alpha-monooxygenase; cholesterol 7-alpha-hydroxylase;...
  • Protein Biological Process 3: Cholesterol metabolism

Product Description
*Specificity: This assay has high sensitivity and excellent specificity for detection of Human CYP7A1. No significant cross-reactivity or interference between Human CYP7A1 and analogues was observed.Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10% Three samples of known concentration were tested in twenty assays to assess.; *Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.; *Accession#: NP_000771.2; NM_000780.3; P22680; *Description: Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CYP7A has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CYP7A present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CYP7A is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CYP7A bound in the initial step. The color development is stopped and the intensity of the color is measured.; *NCBI Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the pr...

Questions & answers

  1. Lud Lud says:
    is the cholesterol knock down in our blood directly related to the cholesterol content of our diet?
    Is this viewpoint generally accepted. Medical Association (April 21, 1999), seem to be compelling the position that the link between dietary and blood cholesterol is not particularly aggressive.
    Gina C says:
    There are a lot of factors on this one, and the channel one is that people would rather expect people to take a medicate and mind their specific food choices, than to trust them to admit defeat weight.

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  1. LKB1 and AMPK and the cancer-metabolism tie up - ten years after
    Thus, the LKB1-AMPK pathway may act as a tumor suppressor with the aid its ability to restrain the growth of pre-neoplastic lesions, but paradoxically may provoke established tumor cells more resistant to the metabolic stresses induced by biguanides or cytotoxic ...
  2. Lovastatin induces apoptosis from one end to the other the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell way
    ... that neurons are skilful to produce cholesterol 3 even if the mechanisms regulating this pathway remain unclear. The testimony that cholesterol biosynthesis deregulation is involved in neurodegenerative diseases gave new pertinacity to the studies focused on ...

Explore: Association of high cholesterol levels with nerve spoil

Lipid profiles. METHODS: This about enrolled 136 patients with MS (n = 272 eyes. A subset of 88 patients received criterion reversal visual-evoked potential (PRVEP) testing. 45% had a curriculum vitae of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts.
Source: http://multiple-sclerosis-research.blogspot.com/2013/04/research-association-of-high.html

Google news feed

  1. Reconstruction of the biosynthetic pathway for the substance fungal polyketide ...
    Fungal polyketides classify commercially important pharmaceuticals and food additives, e.g. the cholesterol-lowering statins and the red and orange monascus pigments. Shortly, production relies on isolation of the compounds from the organically grown
  2. Using biology to take a new lease on life chemical synthesis
    One such aggravate, 3-hydroxyg-butyrolactone (3HBL), can be widely reach-me-down in the pharmaceutical industry as a chiral building shut off for the statin class of cholesterol-reducing drugs such as Crestor and Lipitor, as clearly as the antibiotic Zyvox, and the
  3. Chemistry of Disappearing The bottle: Your Body A Culprit or A Victim? - Body of knowledge 2.0
    Another decision by Min You, et al (2009) suggests that ethanol induces fatty acid merge pathway by activation of the Sterol RegulatoryElement-Binding Protein (SREBP). SREBP is a transcription cause that binds with DNA and can trigger the synthesis
  4. הדוקטור- פורטל בריאות ורפואה שמן קריל כנגד דלקות וארתריטיס
    Fresh risk factors for systemic atherosclerosis: a contrast of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and guide cholesterol screening as predictors of peripheral arterial disorder. JAMA 285: leukotriene biosynthesis by the leukocyte upshot 15-hydroxy-5,8,11,13- eicosatetraenoic acid. J Biol Chem 255; Effects of exogenous arachidonic, eicosapentaenoic and docosahexaenoic acids on the epoch of 5-lipoxygenase pathway products by ionophore-activated individual neutrophils.
Schematic representation of the cholesterol biosynthesis pathway, with ...
Schematic representation of the cholesterol biosynthesis pathway, with ...
www.biomedcentral.com - Figure
www.biomedcentral.com - Figure
cholesterol+biosynthesis+pathway.gif
cholesterol+biosynthesis+pathway.gif
Several hydroxysterol compounds formed from cholesterolby ...
Several hydroxysterol compounds formed from cholesterolby ...