Form: Supplied as a liquid in PBS, 0.09% sodium azide.
Purity: Affinity Purified Purified by Protein G affinity...
SynName: Anti -FDFT1, ID (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase); FDFT1, ID (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase); *AppNotes: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:200 Immunohistochemistry: 1:50-1:100; *Specificity: Recognizes human FDFT1.Immunogen: Synthetic peptide selected from the center region of human FDFT1 (KLH).; *Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.; *Accession#: Q6IAX1; *Description: FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites. ; *NCBI Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq]
*Storage: Store all reagents at 2-8 degree C; *Accession#: CAG33314.1; Q6IAX1; *NCBI Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Questions & answers
is the cholesterol knock down in our blood directly related to the cholesterol content of our diet?
Is this viewpoint generally accepted. Medical Association (April 21, 1999), seem to be compelling the position that the link between dietary and blood cholesterol is not particularly aggressive.
There are a lot of factors on this one, and the channel one is that people would rather expect people to take a medicate and mind their specific food choices, than to trust them to admit defeat weight.
131-Cholesterol Synthesis & Transport
Overview of general steps in cholesterol synthesis. transport of cholesterol to and from cells.
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Thus, the LKB1-AMPK pathway may act as a tumor suppressor with the aid its ability to restrain the growth of pre-neoplastic lesions, but paradoxically may provoke established tumor cells more resistant to the metabolic stresses induced by biguanides or cytotoxic ...
Lovastatin induces apoptosis from one end to the other the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell way
... that neurons are skilful to produce cholesterol 3 even if the mechanisms regulating this pathway remain unclear. The testimony that cholesterol biosynthesis deregulation is involved in neurodegenerative diseases gave new pertinacity to the studies focused on ...
Explore: Association of high cholesterol levels with nerve spoil
Lipid profiles. METHODS: This about enrolled 136 patients with MS (n = 272 eyes. A subset of 88 patients received criterion reversal visual-evoked potential (PRVEP) testing. 45% had a curriculum vitae of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts.
Reconstruction of the biosynthetic pathway for the substance fungal polyketide ...
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One such aggravate, 3-hydroxyg-butyrolactone (3HBL), can be widely reach-me-down in the pharmaceutical industry as a chiral building shut off for the statin class of cholesterol-reducing drugs such as Crestor and Lipitor, as clearly as the antibiotic Zyvox, and the
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Another decision by Min You, et al (2009) suggests that ethanol induces fatty acid merge pathway by activation of the Sterol RegulatoryElement-Binding Protein (SREBP). SREBP is a transcription cause that binds with DNA and can trigger the synthesis
שמן קריל כנגד דלקות וארתריטיס
Fresh risk factors for systemic atherosclerosis: a contrast of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and guide cholesterol screening as predictors of peripheral arterial disorder. JAMA 285: leukotriene biosynthesis by the leukocyte upshot 15-hydroxy-5,8,11,13- eicosatetraenoic acid. J Biol Chem 255; Effects of exogenous arachidonic, eicosapentaenoic and docosahexaenoic acids on the epoch of 5-lipoxygenase pathway products by ionophore-activated individual neutrophils.
Schematic representation of the cholesterol biosynthesis pathway, with ...
www.biomedcentral.com - Figure
Several hydroxysterol compounds formed from cholesterolby ...
B0004732 HMG-CoA reductase
Credit: T. Greenhough & A. Shrive. Wellcome Images
Molecular model of human enzyme HMG-CoA reductase. This enzyme catalyses the first step in...