cholesterol biosynthesis pathway
This new volume of Methods in Cell Biology
looks at methods for lysosomes and lysosomal diseases. Chapters focus upon practical experimental protocols to guide researchers through the analysis of multiple aspects of lysosome biology and function. In addition, it details protocols relevant to clinical monitoring of patients with lysosomal diseases. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.
- Covers sections on model systems and functional studies, imaging-based approaches and emerging studies
- Chapters are written by experts in the field
- Cutting-edge material
*Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein@@Endotoxin Level: ; *Accession#: NP_004453.3; NM_004462.4; P37268; *Description: About the Marker: Effective Size Range: 10kDa to 70kDa.Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.Ready-to-use: No need to heat, dilute or add reducing agents before use.; *NCBI Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]; *Uniprot Summary: Catalytic activity: 2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.Cofactor: Magnesium.Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.Subunit structure: Monomer By similarity.Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sequence similarities: Belongs to the phytoene/squalene synthase family.
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Explore: Association of high cholesterol levels with nerve spoil
Lipid profiles. METHODS: This about enrolled 136 patients with MS (n = 272 eyes. A subset of 88 patients received criterion reversal visual-evoked potential (PRVEP) testing
. 45% had a curriculum vitae of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts.
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Schematic representation of the cholesterol biosynthesis pathway, with ...
www.biomedcentral.com - Figure
Several hydroxysterol compounds formed from cholesterolby ...