cholesterol biosynthesis pathway

Featured Products

FDFT1, ID (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnes...
$500.00
FDFT1, ID (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnes... by MyBioSource

  • FDFT1; FDFT1 protein; squalene synthase; OTTHUMP00000116011;...
  • Form: Supplied as a liquid in PBS, 0.09% sodium azide.
  • Purity: Affinity Purified Purified by Protein G affinity...

Product Description
SynName: Anti -FDFT1, ID (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase); FDFT1, ID (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase); *AppNotes: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:200 Immunohistochemistry: 1:50-1:100; *Specificity: Recognizes human FDFT1.Immunogen: Synthetic peptide selected from the center region of human FDFT1 (KLH).; *Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.; *Accession#: Q6IAX1; *Description: FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites. ; *NCBI Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq]
Human Farnesyl Diphosphate Farnesyl transferase 1 ELISA Kit (ELISA Kit)
$600.00
Human Farnesyl Diphosphate Farnesyl transferase 1 ELISA Kit (ELISA Kit) by MyBioSource

  • GeneName: FDFT1; SS; SQS; DGPT; ERG9
  • SynName: FDFT1; FDFT1 protein; squalene synthase; squalene...
  • Reactivity: Human; *ELISA Type: Sandwich

Product Description
*Storage: Store all reagents at 2-8 degree C; *Accession#: CAG33314.1; Q6IAX1; *NCBI Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Questions & answers

  1. Lud Lud says:
    is the cholesterol knock down in our blood directly related to the cholesterol content of our diet?
    Is this viewpoint generally accepted. Medical Association (April 21, 1999), seem to be compelling the position that the link between dietary and blood cholesterol is not particularly aggressive.
    Gina C says:
    There are a lot of factors on this one, and the channel one is that people would rather expect people to take a medicate and mind their specific food choices, than to trust them to admit defeat weight.

131-Cholesterol Synthesis & Transport

Overview of general steps in cholesterol synthesis. transport of cholesterol to and from cells.

  1. LKB1 and AMPK and the cancer-metabolism tie up - ten years after
    Thus, the LKB1-AMPK pathway may act as a tumor suppressor with the aid its ability to restrain the growth of pre-neoplastic lesions, but paradoxically may provoke established tumor cells more resistant to the metabolic stresses induced by biguanides or cytotoxic ...
  2. Lovastatin induces apoptosis from one end to the other the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell way
    ... that neurons are skilful to produce cholesterol 3 even if the mechanisms regulating this pathway remain unclear. The testimony that cholesterol biosynthesis deregulation is involved in neurodegenerative diseases gave new pertinacity to the studies focused on ...

Explore: Association of high cholesterol levels with nerve spoil

Lipid profiles. METHODS: This about enrolled 136 patients with MS (n = 272 eyes. A subset of 88 patients received criterion reversal visual-evoked potential (PRVEP) testing. 45% had a curriculum vitae of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts.
Source: http://multiple-sclerosis-research.blogspot.com/2013/04/research-association-of-high.html

Google news feed

  1. Reconstruction of the biosynthetic pathway for the substance fungal polyketide ...
    Fungal polyketides classify commercially important pharmaceuticals and food additives, e.g. the cholesterol-lowering statins and the red and orange monascus pigments. Shortly, production relies on isolation of the compounds from the organically grown
  2. Using biology to take a new lease on life chemical synthesis
    One such aggravate, 3-hydroxyg-butyrolactone (3HBL), can be widely reach-me-down in the pharmaceutical industry as a chiral building shut off for the statin class of cholesterol-reducing drugs such as Crestor and Lipitor, as clearly as the antibiotic Zyvox, and the
  3. Chemistry of Disappearing The bottle: Your Body A Culprit or A Victim? - Body of knowledge 2.0
    Another decision by Min You, et al (2009) suggests that ethanol induces fatty acid merge pathway by activation of the Sterol RegulatoryElement-Binding Protein (SREBP). SREBP is a transcription cause that binds with DNA and can trigger the synthesis
  4. הדוקטור- פורטל בריאות ורפואה שמן קריל כנגד דלקות וארתריטיס
    Fresh risk factors for systemic atherosclerosis: a contrast of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and guide cholesterol screening as predictors of peripheral arterial disorder. JAMA 285: leukotriene biosynthesis by the leukocyte upshot 15-hydroxy-5,8,11,13- eicosatetraenoic acid. J Biol Chem 255; Effects of exogenous arachidonic, eicosapentaenoic and docosahexaenoic acids on the epoch of 5-lipoxygenase pathway products by ionophore-activated individual neutrophils.
Schematic representation of the cholesterol biosynthesis pathway, with ...
Schematic representation of the cholesterol biosynthesis pathway, with ...
www.biomedcentral.com - Figure
www.biomedcentral.com - Figure
cholesterol+biosynthesis+pathway.gif
cholesterol+biosynthesis+pathway.gif
Several hydroxysterol compounds formed from cholesterolby ...
Several hydroxysterol compounds formed from cholesterolby ...