cholesterol ester transfer protein

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Product Description
The BioAssayTM ELISA Kit is a 1.5 hour solid-phase Sandwich ELISA designed for the quantitative determination of Cholesterol Ester Transfer Protein/Lipid Transfer Protein (CETP/LTP) (Rat). This kit for research use only, not for therapeutic or diagnostic applications. Assay Principle: Cholesterol Ester Transfer Protein/Lipid Transfer Protein (CETP/LTP) BioAssayTM ELISA Kit (Rat) utilizes the quantitative Sandwich Enzyme Immunoassay technique. The microtiter plate has been pre-coated with a monoclonal antibody specific for Cholesterol Ester Transfer Protein/Lipid Transfer Protein (CETP/LTP) (Rat). Standards or samples are then added to the microtiter plate wells and if the protein is present, will bind to the antibody pre-coated wells. In order to quantitatively determine the amount of protein present in the sample, a standardized preparation of horseradish peroxidase (HRP)-conjugated polyclonal antibody, specific for the protein are added to each well to "sandwich" the protein immobilized on the plate. The microtiter plate undergoes incubation, and then the wells are thoroughly washed to remove all unbound components. Next, substrate solutions are added to each well. The enzyme (HRP) and substrate are allowed to react over a short incubation period. Only those wells that contain the target protein and enzyme-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by addition of a sulfuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The protein concentration in each sample is interpolated from this standard curve. Kit Detection Range: 0.5-10ng/mL Kit Sensitivity: 0.1ng/ml Materials and Equipment Supplied: 1. Microtiter Plate, 96 wells, stripwell 2. Enzyme Conjugate, 10mL, 1 vial 3. Standard A, 0ng/mL, 1 vial 4. Standard B, 0.5ng/mL, 1 vial 5. Standard C, 1.0ng/mL, 1
Product Description
Cardiovascular diseases are an important cause of mortality worldwide. They are an entity of diseases of the heart and vasculature, mainly caused by atherosclerosis. In atherosclerosis, cholesterol accumulates in the vessel wall, mainly in the form of low-density lipoprotein (LDL). High-density lipoprotein (HDL) protects against atherosclerosis, as HDL particles accept cellular cholesterol and transport it to the liver for excretion in a process called reverse cholesterol transport (RCT). Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) are two key lipid transfer proteins responsible for the remodeling of HDL particles. The aim of this thesis was to clarify the role of PLTP and CETP in RCT. The results indicate that both PLTP and CETP can remodel HDL as a cholesterol acceptor, which affects the removal of cholesterol from foam cells. This thesis is useful to anyone interested in lipid metabolism. It gives the reader a basic knowledge about the development of atherosclerosis and factors affecting that. It is also useful to professionals giving also a deeper insight to the world of lipid metabolism.

Questions & answers

  1. Johanna Johanna says:
    What is the fame of the protein that alows sharks to regrow teeth rapidly?
    A shark can become more pleasing to mature it back rapidly, so what is the name for that protien. I'm doing a project for my school inwich we have to transfer a protein of one preoccupation to another to solve an issue and the issue i told was people loosing teeth.
    Maria10points says:
    bone morphogenic protein 4 (BMP4)
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    The Bezafibrate Infarction Halting (BIP) Study. Circulation 102: 21-27 Tall AR (1993) Plasma cholesteryl ester transfer protein. J Lipid Res 34: 1255-1274 Brown ML et al. (1989) Molecular foundation of lipid transfer protein deficiency in a family with ...
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Cholesteryl Ester Transfer Protein (CETP) Inhibitor: Dormant of ...

AstraZeneca property of AlphaCore represents its market entry into the  CETP inhibitor  component via an acquisition where the. The ability of anacetrapib to reduce coronary virus events is being tested in the Randomized EValuation of the Effects of Anacetrapib Middle of Lipid-modification (REVEAL) trial (NCT01252953).
Source: http://pharmaceuticalintelligence.com/2013/04/07/cholesteryl-ester-transfer-protein-cetp-inhibitor-potential-of-anacetrapib-to-treat-atherosclerosis-and-cad/

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The Inhibition of Cholesteryl Ester Transfer Protein
The Inhibition of Cholesteryl Ester Transfer Protein
reverse cholesterol transport cholesteryl ester transfer protein ...
reverse cholesterol transport cholesteryl ester transfer protein ...
hdl-lipid-CEPT-cholesteryl ester-transfer-protein-cholesterol ...
hdl-lipid-CEPT-cholesteryl ester-transfer-protein-cholesterol ...
Entity page for cholesteryl ester transfer protein
Entity page for cholesteryl ester transfer protein