cholesteryl ester transfer protein

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Cardiovascular diseases are an important cause of mortality worldwide. They are an entity of diseases of the heart and vasculature, mainly caused by atherosclerosis. In atherosclerosis, cholesterol accumulates in the vessel wall, mainly in the form of low-density lipoprotein (LDL). High-density lipoprotein (HDL) protects against atherosclerosis, as HDL particles accept cellular cholesterol and transport it to the liver for excretion in a process called reverse cholesterol transport (RCT). Phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) are two key lipid transfer proteins responsible for the remodeling of HDL particles. The aim of this thesis was to clarify the role of PLTP and CETP in RCT. The results indicate that both PLTP and CETP can remodel HDL as a cholesterol acceptor, which affects the removal of cholesterol from foam cells. This thesis is useful to anyone interested in lipid metabolism. It gives the reader a basic knowledge about the development of atherosclerosis and factors affecting that. It is also useful to professionals giving also a deeper insight to the world of lipid metabolism.
Product Description
ANTI-CHOLESTERYL ESTER TRANSFER PROTEIN 100UG

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  1. Synageva BioPharma™ Joins the Supranational MPS Network in Support of MPS Awareness Day 2013
    Current onset LAL Deficiency, sometimes called Cholesteryl Ester Storage Affliction (CESD), is an underappreciated ... Synageva has several protein therapeutics in its dope development pipeline. Further information regarding Synageva BioPharma Corp ...
  2. New Clinical Pharmacology Work Findings Have Been Reported from Merck & Company
    A sedative interaction study for warfarin with a novel CETP inhibitor is expected to be useful in defining dosing regimens. WHAT THIS STUDY: ADDS This is the triumph study to show that there is no clinically meaningful pharmacokinetic interaction ...
  3. Sequencing of superagers offers medicament targets, but fewer than hoped
    one of the two big pharma firms with CETP inhibitors now in late-acting clinical development. Studies involving centenarians and nonagenerians have also linked outstanding variants of the human forkhead box O3A (FOXO3A) gene and the apolipoprotein ...

Will Cholesteryl Ester Transfer Protein Check Succeed Primarily

Myriad new drugs fail in the clinic because of efficacy, that is, the dose does not reduce risk for ASCVD. Developing new medicines to go into atherosclerotic cardiovascular disease (ASCVD), the paramount cause of death in the United States and in Europe, has not been more challenging ( 1 ). The number of new drug approvals is down, whereas the tariff of...
Source: http://content.onlinejacc.org/article.aspx?articleid=1378219

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  1. Monthly Prescribing Reference Mediterranean Fast Improves Cholesterol Measures
    The researchers found that MedDiet-WL significantly reduced bare-low-density lipoprotein (VLDL)-apoCIII (−41.5%), cholesteryl ester transfer protein (-7%), and hepatic lipase concentrations (-7.1%). It also reduced the dimensions of small LDL (<255 Å;
  2. Merck In-Licenses from Xenon
    Merck's cardiovascular duct includes candidates like MK-0859, anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor which is being developed for cholesterol governance. Merck has started a large, event-driven cardiovascular clinical
2obd » Cholesteryl ester transfer protein - Orientations of Proteins ...
2obd » Cholesteryl ester transfer protein - Orientations of Proteins ...
Cholesteryl ester transfer protein - Stock Image C013/8895 - Science ...
Cholesteryl ester transfer protein - Stock Image C013/8895 - Science ...
Entity page for cholesteryl ester transfer protein
Entity page for cholesteryl ester transfer protein
... Of HDL Therapy?: HDL Metabolism & Cholesteryl Ester Transfer Protein
... Of HDL Therapy?: HDL Metabolism & Cholesteryl Ester Transfer Protein