cholesteryl ester transfer protein

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Human CETP (Cholesteryl Ester Transfer Protein) ELISA Kit (ELISA Kit)
Human CETP (Cholesteryl Ester Transfer Protein) ELISA Kit (ELISA Kit) by MyBioSource

  • Reactivity: Human
  • Storage: Store at 4 degree C.
  • cholesteryl ester transfer protein, plasma; Lipid transfer protein I

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Product Description
*Specificity: This kit recognizes natural and recombinant Human CETP. No significant cross-reactivity or interference between Human CETP and analogues was observed.Samples: Serum, plasma and other biological fluids.; *Sensitivity: The minimum detectable dose of Human CETP is 0.188ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero).; *Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human CETP concentrations in serum, plasma and other biological fluids.; *Accession#: NP_001273014.1; NM_001286085.1; P11597; *Description: Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CETP. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CETP and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CETP, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CETP. You can calculate the concentration of CETP in the samples by comparing the OD of the samples to the standard curve.
Product Description
There is overwhelming evidence that both elevated low-density lipoprotein (LDL) cholesterol and reduced high-density lipoprotein (HDL) cholesterol are independently associated with a substantially increased risk of developing premature atherosclerotic cardiovascular disease. Furthermore, the risk associated with low HDL cholesterol persists even when the level of LDL cholesterol has been reduced to levels below 70 mg/dL (1.8 mmol/L) by treatment with statins. This has led to a major research effort to discover therapies with the capacity to raise HDL cholesterol as effectively as statins lower LDL cholesterol. One logical approach is to find ways to shift the partitioning of cholesterol between LDLs and HDL towards the HDL fraction. Given that human plasma contains the cholesteryl ester transfer protein (CETP) that promotes the transfer of cholesterol from HDLs to LDLs, inhibition of this protein has the potential to shift the balance of plasma cholesterol in favour of the protective HDL fraction. The possibility that CETP may be pro-atherogenic by transferring cholesterol from the anti-atherogenic HDL fraction to pro-atherogenic particles in the very low-density lipoprotein (VLDL) and LDL fractions was first raised more than 15 years ago. This provided the rationale for a major research effort to test the possibility that inhibition of CETP may be anti-atherogenic. The updated version of this book documents the physiological functions of CETP, its possible contribution to the development of atherosclerosis and the evidence that its inhibition may translate into a protection against atherosclerosis.

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  1. Synageva BioPharma™ Joins the Supranational MPS Network in Support of MPS Awareness Day 2013
    Current onset LAL Deficiency, sometimes called Cholesteryl Ester Storage Affliction (CESD), is an underappreciated ... Synageva has several protein therapeutics in its dope development pipeline. Further information regarding Synageva BioPharma Corp ...
  2. New Clinical Pharmacology Work Findings Have Been Reported from Merck & Company
    A sedative interaction study for warfarin with a novel CETP inhibitor is expected to be useful in defining dosing regimens. WHAT THIS STUDY: ADDS This is the triumph study to show that there is no clinically meaningful pharmacokinetic interaction ...
  3. Sequencing of superagers offers medicament targets, but fewer than hoped
    one of the two big pharma firms with CETP inhibitors now in late-acting clinical development. Studies involving centenarians and nonagenerians have also linked outstanding variants of the human forkhead box O3A (FOXO3A) gene and the apolipoprotein ...

Will Cholesteryl Ester Transfer Protein Check Succeed Primarily

Myriad new drugs fail in the clinic because of efficacy, that is, the dose does not reduce risk for ASCVD. Developing new medicines to go into atherosclerotic cardiovascular disease (ASCVD), the paramount cause of death in the United States and in Europe, has not been more challenging ( 1 ). The number of new drug approvals is down, whereas the tariff of...
Source: http://content.onlinejacc.org/article.aspx?articleid=1378219

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  1. Monthly Prescribing Reference Mediterranean Fast Improves Cholesterol Measures
    The researchers found that MedDiet-WL significantly reduced bare-low-density lipoprotein (VLDL)-apoCIII (−41.5%), cholesteryl ester transfer protein (-7%), and hepatic lipase concentrations (-7.1%). It also reduced the dimensions of small LDL (<255 Å;
  2. Merck In-Licenses from Xenon
    Merck's cardiovascular duct includes candidates like MK-0859, anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor which is being developed for cholesterol governance. Merck has started a large, event-driven cardiovascular clinical
2obd » Cholesteryl ester transfer protein - Orientations of Proteins ...
2obd » Cholesteryl ester transfer protein - Orientations of Proteins ...
Cholesteryl ester transfer protein - Stock Image C013/8895 - Science ...
Cholesteryl ester transfer protein - Stock Image C013/8895 - Science ...
Entity page for cholesteryl ester transfer protein
Entity page for cholesteryl ester transfer protein
... Of HDL Therapy?: HDL Metabolism & Cholesteryl Ester Transfer Protein
... Of HDL Therapy?: HDL Metabolism & Cholesteryl Ester Transfer Protein